Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection

Immunohistochemical study of hair follicle stem cells in regenerated hair follicles induced by Wnt10b

The regulation of the periodic regeneration of hair follicles is complicated. Although Wnt10b has been reported to induce hair follicle regeneration, the characteristics of induced hair follicles, especially the target cells of Wnt10b, have not yet been clearly elucidated. Thus, we systematically evaluated the expression and proliferation patterns of Wnt10b-induced hair follicles. We found that...

Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds.

During natural aging, adult stem cells are known to have a reduced restorative capacity and are more vulnerable to oxidative stress resulting in a reduced ability of the body to heal itself. We report here that the proprietary natural product formulation, NT020, previously found to promote proliferation of human hematopoietic stem cells, reduced oxidative stress-induced apoptosis of murine neur...

Stem Cells of Human Hair Follicles Can Differentiate Into Neurons: Region-Specific Multipotency of Human Hair Follicle Stem Cells

Hair follicle stem cells in the hair follicle bulge area of mice are nestinand CD34-positive, and keratin 15 (K15)negative. The mouse hair follicle stem cells are multipotent and can differentiate into neurons, glial cells, keratinocytes, smooth muscle cells, and melanocytes (Proc. Natl. Acad. Sci. USA 102, 5530-5534, 2005). Recently, pluripotent stem cells have been identified in human hair fo...

Protection of Mouse Embryonic Stem Cells from Oxidative Stress by Methionine Sulfoxide Reductases

Targeting to the hair follicles: current status and potential.

The pilosebaceous unit is a complex structure that undergoes a specific growth cycle and comprises a few important drug targeting sites. For example, drugs can be targeted to the bulge region with stem cells or to the sebaceous glands. Interest in pilosebaceous units is directed towards their utilization as reservoirs for localized therapy and also as a transport pathway for systemic drug deliv...